GENOMICS OF IN-STENT RESTENOSIS

摘要

Described herein is the identification of sixteen candidate susceptibility loci linked to in-stent restenosis (ISR). Of these regions, seven contain the genes NOV, ARNTL, TAF4B, PKP4, EPHB l, ST 18 and FLJ21986 (which encodes a hypothetical protein). The remaining eleven susceptibility loci are located in cytobands 2p 16.1, 4q31.21, 7p21.2, Ip31.1, 2p24.1, 2q22.3, 13ql4.3, 15q25.1 and 18q22.3. Provided are methods for identifying a subject having an increased risk of developing restenosis, comprising obtaining a nucleic acid sample from the subject and determining the nucleotide present at the chromosomal positions identified herein as part of a haplotype associated with an increased risk of developing restenosis.