HEMATOPOIESIS AND REGULATION THEREOF BY ETS RELATED GENE (Erg)

摘要

Methods are provided for modulating hematopoietic cell activity comprising modulating the level or activity of ets-related gene (Erg) polypeptide or a transcriptional target of Erg polypeptide or a downstream effector of Erg polypeptide activity. Hematopoietic cells also include erthrocytes and leukocytes. Hematopoietic cells include hematopoietic stem cells (HSCs) and hematopoietic progenitor cells. Hematopoietic cell activity includes one or more functions including homing, engrafting, survival, self-renewal and differentiation. Methods are also provided for screening for modulators of hematopoietic cell activity. Modulators based inter alia on Erg gene-silencing or the administration of Erg polypeptide-encoding sequences are also described.