ANTIBODIES TO UROKINASE- TYPE PLASMINOGEN ACTIVATOR RECEPTOR(UPAR)BIND CANCER STEM CELLS: USE IN DIAGNOSIS AND THERAPY

摘要

Cancer or tumor stem cells (CaSCs) express urokinase-type plasminogen activator receptor (uPAR) on their surfaces. Ligands of uPAR, in particular antibodies are used to bind, detect, inactivate or purge uPAR-expressing cancer stem cells. Such antibodies or other ligands are also used in methods for diagnosing and treating cancer.