METHODS OF PREVENTING, TREATING OR AMELIORATING ENHANCED RESPIRATORY DISEASE VIA INNATE IMMUNE MECHANISMS

摘要

The present invention encompasses methods of preventing, treating or ameliorating bronchiolitis, ARDS, or asthma or a symptom thereof, the method comprising administering to a patient an effective amount of an anti-inflammatory, wherein the anti-inflammatory is selected from the group consisting of an isolated anti-human HMGBl monoclonal antibody or fragment thereof, an isolated anti-interferon alpha monoclonal antibody or fragment thereof, an isolated anti-interferon receptor monoclonal antibody or fragment thereof, an isolated anti-CD 19 monoclonal antibody or fragment thereof, an isolated anti-CD20 monoclonal antibody or fragment thereof, an isolated anti-CD21 monoclonal antibody or fragment thereof, an isolated anti-BAFF monoclonal antibody or fragment thereof, an isolated anti-BAFF receptor monoclonal antibody or fragment thereof, or an isolated mast cell product antagonist that may further be in combination with an anti-viral, wherein said anti-viral is one or more antibodies or fragments thereof that immunospecifically bind to one or more RSV antigens or is a synthetic anti-viral compound.