A method of operating a baroreflex therapy system (102) includes providing an implantable baroreflex activation device (100), providing a sensing arrangement (116, 118), and providing a controller (104) in operable communication with the baroreflex activation device and the sensing arrangement (116, 118). The sensing arrangement (116, 118) is used to measure cardiac electrical activity of a patient to generate cardiac electrical activity data. The cardiac electrical activity data is communicated to the controller (104), wherein the controlled 104) performs heart rate variability analysis based on the cardiac electrical activity data. An indication of results of the heart rate variability analysis are provided, upon which a determination may be made to adjust a baroreflex therapy to be delivered by the implantable baroreflex activation device (100).
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