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COMPOUNDS THAT INTERACT WITH ION CHANNELS, IN PARTICULAR WITH ION CHANNELS FROM THE KV FAMILY

机译:与离子通道相互作用的化合物,特别是与KV家族中的离子通道相互作用的化合物

摘要

The present invention relates to compounds that interact with ion channels. In particular, the invention relates to compounds having the structural Formula I or II, stereoisomers, tautomers, racemics, prodrugs, metabolites thereof, or a pharmaceutically acceptable salt and/or solvate thereof, wherein XSUP1/SUP, XSUP2/SUP, XSUP3/SUP, XSUP4/SUP, RSUP1/SUP, RSUP2/SUP, RSUP3/SUP, ZSUP1/SUP, LSUP1/SUP, m and n have the same meaning as that defined in claim 1. The invention also relates to methods for preparing said compounds, to pharmaceutical compositions comprising said compounds, and to the use of said compounds in methods for treatment of the human and animal body.
机译:本发明涉及与离子通道相互作用的化合物。特别地,本发明涉及具有结构式I或II的化合物,其立体异构体,互变异构体,外消旋体,前药,其代谢产物或其药学上可接受的盐和/或溶剂化物,其中X 1 ,X 2 ,X 3 ,X 4 ,R 1 ,R 2 ,R 3 ,Z 1 ,L 1 ,m和n与权利要求1中定义的含义相同。本​​发明还涉及用于制备所述化合物,包含所述化合物的药物组合物以及所述化合物在治疗人和动物体的方法中的用途。

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