A PHARMACEUTICAL COMPOSITION FOR ORAL COMPRISING FENOFIBRATE AND PREPARATION METHOD THEREOF

摘要

The present invention relates to an oral pharmaceutical composition comprising the fenofibrate and a preparation method thereof. More specifically, the present invention is directed to an orally-administered pharmaceutical composition with improved bioavailability for treating hyperlipidemia and the preparation method thereof, where the solid dispersion is prepared by spray-drying a mixture of 100 parts by weight of fenofibrate dispersed in 20-200 parts by weight of water-soluble polymer, and 5-50 parts by weight of surfactant. The oral pharmaceutical composition has high bioavailability because of the increased solubility of amorphous fenofibrate. In addition, the spraying and drying can be performed at a time and low temperature, and thus a loss of activity of drug can be minimized, unlike the mechanical milling method.