SYSTEMS AND METHODS FOR ANALYZING GENE EXPRESSION DATA FOR CLINICAL DIAGNOSTICS

摘要

Methods, computer program products and computer systems for constructing a classifier for classifying a specimen into a class are provided. The classifiers are models. Each model includes a plurality of tests. Each test specifies a mathematical relationship (e.g., a ratio) between the characteristics of specific cellular constituents. Each test is polled using characteristic values of these specified cellular constituents from the biological specimen to be classified. In some embodiments, each test has a positive threshold and a negative threshold. When the value of the test exceeds the positive threshold, the test polls positive. When the value of the test is below the negative threshold, the test polls negative. When the value of the test is between the negative threshold and the positive threshold, the test polls indeterminate. The value of each test is combined to provide a composite score. In some embodiments, positive composite scores indicate that the specimen belongs in the class associated with the model.