TRANSDERMAL ELECTROTRANSPORT DRUG DELIVERY SYSTEMS WITH REDUCED ABUSE POTENTIAL

摘要

A transdermal electrotransport drug delivery system having reduced potential for abuse. The system uses ion barrier (112, 124, 130, 140, 162, 168), preferentially ion exchange material to separate the drug (110, 122, 136, 148, 154, 170) from an antagonist and provides for the release of the antagonist (116, 128, 132, 138, 164) with the agonist when the system is subject to abuse. In a preferred embodiment, the barrier has a weak area which breaks when under stress or placed in solvent. In another preferred embodiment, the barrier is a dialysis membrane.