首页> 外国专利> HUMANIZED ANTI-EPHB4 ANTIBODIES AND THEIR USE IN TREATMENT OF ONCOLOGY AND VASCULOGENESIS-RELATED DISEASE

HUMANIZED ANTI-EPHB4 ANTIBODIES AND THEIR USE IN TREATMENT OF ONCOLOGY AND VASCULOGENESIS-RELATED DISEASE

机译：人源化抗EPHB4抗体及其在肿瘤和血管增生相关疾病的治疗中的应用

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摘要

The present invention provides humanized versions of anti-EphB4 mouse monoclonal antibodies. The invention further relates to pharmaceutical compositions, immunotherapeutic compositions, and methods using therapeutic antibodies that bind to the human EphB4 antigen and that may mediate ADCC, CDC, and/or apoptosis for the treatment of human malignancies and vasculogenesis-related disorders and diseases.

机译：本发明提供了抗EphB4小鼠单克隆抗体的人源化形式。本发明进一步涉及使用与人EphB4抗原结合并且可以介导ADCC，CDC和/或凋亡的治疗性抗体的药物组合物，免疫治疗组合物和方法，用于治疗人类恶性肿瘤和与血管生成有关的病症和疾病。

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公开/公告号WO2008042941A2

专利类型
公开/公告日2008-04-10

原文格式PDF
申请/专利权人 MEDIMMUNE LLC;DAMSCHRODER MELISSA;DALLACQUA WILLIAM;WU HERREN;BOWDEN EMMA T.;
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申请/专利号WO2007US80270
发明设计人 WU HERREN;DALLACQUA WILLIAM;BOWDEN EMMA T.;DAMSCHRODER MELISSA;
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申请日2007-10-03
分类号C12P21/08;C07H21/04;A61K39/395;
国家 WO
入库时间 2022-08-21 20:00:04

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