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Vectors/DNA-sequences from human combinatorial antibody libraries
Vectors/DNA-sequences from human combinatorial antibody libraries
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机译:人源组合抗体库中的载体/ DNA序列
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摘要
The present invention relates to synthetic DNA sequences which encode one or more collections of homologous proteins/(poly)peptides, and methods for generating and applying libraries of these DNA sequences. In particular, the invention relates to the preparation of a library of human-derived antibody genes by the use of synthetic consensus sequences which cover the structural repertoire of antibodies encoded in the human genome. Furthermore, the invention relates to the use of a single consensus antibody gene as a universal framework for highly diverse antibody libraries.
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