Use of mixtures of active compounds comprising azelaic acid and glycyrrhetic acid in the treatment of acne

摘要

Combination (I) of azelaic acid and glycyrrhetic acid or their derivatives is used to produce a medicament for treating acne. Independent claims are also included for: (1) production of microcapsules with an average diameter of 0.0001-5 mm by either: (a) forming a matrix of a gelling agent, chitosan and (I), optionally dispersing the matrix in an oil phase, adding an aqueous solution of an anionic polymer and optionally removing the oil phase; (b) forming a matrix of a gelling agent, an anionic polymer and (I), optionally dispersing the matrix in an oil phase, adding an aqueous chitosan solution and optionally removing the oil phase; or (c) forming an oil-in-water emulsion from an aqueous preparation of (I) and an oil in the presence of an emulsifier, adding an aqueous solution of an anionic polymer, contacting the resulting matrix with an aqueous chitosan solution and separating the encapsulated product from the aqueous phase; (2) production of proliposomal mixtures by treating (I) with lecithin and/or phospholipids in a solvent; (3) microcapsules and proliposomal mixtures produced as above.