首页>
外国专利>
LOW-MOLECULAR WEIGHT, WATER-SOLUBLE CHITOSAN NANOPARTICLE FOR GENE DELIVERY WITH FOLIC ACID CONJUGAED THERETO AS TARGET LIGAND AND PREPARATION METHOD THEREOF
LOW-MOLECULAR WEIGHT, WATER-SOLUBLE CHITOSAN NANOPARTICLE FOR GENE DELIVERY WITH FOLIC ACID CONJUGAED THERETO AS TARGET LIGAND AND PREPARATION METHOD THEREOF
展开▼
机译:低分子量,水溶性壳聚糖纳米粒子及其作为目标配体的共轭叶酸转运基因及其制备方法
展开▼
页面导航
摘要
著录项
相似文献
摘要
Disclosed are low-molecular weight, water-soluble chitosan nanoparticles with folic acid conjugated thereto as a target ligand and a preparation method thereof. The nanoparticles can be simply prepared since the strong reactivity of the chitosan allows folic acid to be readily introduced thereinto. Also, the folic acid-conjugated, low-molecular weight, water-soluble chitosan nanoparticles can be useful as gene carriers because they are of low or zero-toxicity, have sizes suitable for use as gene carriers, can readily form complexes with DNA, allow high gene expression rates, and are excellent in targeting tumor cells which are rich in folic acid receptors.
展开▼