PEPTIDES FACILITATING OR INHIBITING ANTEROGRADE TRANSPORT

摘要

The present invention concerns amyloid precursor protein (APP)-based peptide sequences and their uses to facilitate or inhibit anterograde (synapse-directed) transport. The peptide sequences are of the formula GYENPTYX 1X2X3X4X5X6X7X8 (SEQ ID NO: 13), wherein X1 is K, S, or R; X2 is F or Y; X3 is F or L; X4 is E or D; X5 is missing or is Q or E; X6 is M, V, S, or R; X7 is Q, K or P; X8 is missing or is N, E, A or I. The invention further concerns JIP1/2-based peptides, and in particular peptides comprising or consisting of the peptide having the formula FVE YTC PTE DIY LE (SEQ ID NO: 14).