TARGETING OF L-3-HYDROXYACYL-COENZYME A DEHYDROGENASE, SHORT CHAIN (HADHSC) IN DISORDERS OF GLUCOSE HOMEOSTASIS

摘要

The invention provides methods, uses, agents, pharmaceutical formulations and kits for the treatment of disorders of glucose homeostasis and/or for modulating the endogenous production of insulin in subjects. The invention also relates to methods, uses, agents, compositions and kits for modulating the endogenous insulin production by isolated cells or tissues. More in particular, the invention teaches to target L-3-hydroxyacyl-coenzyme A dehydrogenase, short chain (HADHSC). In addition, the invention also provides screening assays to identify agents that modulate the expression and/or the activity of HADHSC and can be useful in the above aspects of the invention.