TARGETING PROHORMONE CONVERTASE ENZYMES TO SUPPRESS POMC-MSH PROCESSING TO INDUCE SKIN LIGHTENING

摘要

Methods and compositions useful for reducing skin pigmentation and hyperpigmentation are provided. The pigmentation or hyperpigmentation reduced according to the methods of the invention can arise independent of a UV-induced tanning response. Also provided are methods for identifying a candidate skin lightening agent. The methods and compositions of the invention are useful for treatment of a number of conditions, including age spots (also variously known as liver spots, sun spots, solar lentigo, and lentigines).