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PURIFICATION PROCESS FOR COAT PROTEIN OF RNA BACTERIOPHAGES
PURIFICATION PROCESS FOR COAT PROTEIN OF RNA BACTERIOPHAGES
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机译:RNA噬菌体外壳蛋白的纯化工艺。
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摘要
The invention relates to aprocess for purifying coat protein of an RNA bacteriophage, wherein said process comprises the steps of disassembling a virus-like particle of an RNA bacteriophage and subsequently purifying said coat protein. The process described herein is designed to be scaled up to produce up to 100 g coat protein and more per batch, and it allows the efficientremoval of RNA and host cell derived impurities, typically below the quantification level. The invention further relates to purified coat protein of RNA bacteriophages, wherein said purified coat protein typically comprises less than 0.5 µg RNA, less than 0.4 IU of endotoxin, less than 5 ng host cell protein, and less than 1.5 ng of host cell DNA per 100 µg of said coat protein.
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