METHODS, SYSTEMS AND APPARATUS FOR IDENTIFYING GENETIC DIFFERENCES IN DISEASE AND DRUG RESPONSE

摘要

Methods for identifying genetic factors associated with, for example, drug response, disease, phenotype and/or behavior. Also provided are systems and apparatus for practicing the methods of the invention. The invention identifies new and informative polymorphisms (not yet identified and relevant to drug response, disease, behavior and/or phenotype) or mutations using a knockout/deletion/removal strategy. Knockout is followed by a step of capturing/trapping/enriching DNA fragments carrying informative polymorphisms or mutations. The advantages of the present invention are beneficial in, for instance, large-scale pharmacogenomics studies in patients undergoing testing in clinical trials or to find new genes associated with disease at relatively low cost.