SYNERGY OF SODIUM CHANNEL BLOCKERS AND CALCIUM CHANNEL BLOCKERS

摘要

Methods are described for suppressing appetite through the intranasal administration of a sodium channel blocker and a calcium channel blocker. It has long been known that smell and taste are an important part of how the body prepares for a meal, for example the cephalic phase of insulin release before a meal. Depressing the sense of smell or taste in subjects prior to meals leads to decreased food intake, which ultimately leads to weight loss. The ability to deliver drugs to the CSF via intranasal application also provides anorexiant central effect.