THERAPEUTIC AGENT FOR PERIODONTAL DISEASE AND ALVEOLAR BONE LOSS DUE TO SURGERY

摘要

According to the invention, it was revealed that by inhibiting transcriptional activation of NF-κB, absorption of alveolar bone is inhibited in a model of periodontal disease, and repair of alveolar bone is promoted in a model of bone loss due to periodontal disease. Accordingly, the invention provides a therapeutic, prophylactic and improving agent for periodontal disease and alveolar bone loss due to surgery or the like containing an active ingredient for inhibiting transcriptional activation of NF-κB such as NF-κB decoy.