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POLYMORPHISMS IN GENES OF THE CRYOPYRIN INFLAMMASOME AND THEIR USES IN THE TREATMENT OF INFLAMMATORY DISEASES
POLYMORPHISMS IN GENES OF THE CRYOPYRIN INFLAMMASOME AND THEIR USES IN THE TREATMENT OF INFLAMMATORY DISEASES
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机译:隐孢子虫炎症基因的多态性及其在治疗炎症性疾病中的应用
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摘要
The present invention relates to a methodfor treatment of a patient suffering from a disease related to polymorphisms in the CIAS1 and/or CARD8 genes characterized in that it comprisesthesteps -obtaining information on polymorphisms in the CIAS1 and/or CARD8 genes in the genome of said patient; -treating said patient with an IL blocking therapy if said patient has at least one polymorphism in the CIAS1 and/or CARD8 genes. The invention further relates to interleukin (IL) inhibitors for use in such methods, to methods for determining if a patient is susceptible to treatment with IL- inhibitorsand kits for use in such methods.
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