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PAXILLIN MUTATIONS, METHODS OF ASSESSING RISK OF METASTASIS AND METHODS OF STAGING TUMORS
PAXILLIN MUTATIONS, METHODS OF ASSESSING RISK OF METASTASIS AND METHODS OF STAGING TUMORS
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机译:帕西林突变,转移风险评估方法和肿瘤分期方法
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摘要
Disclosed herein are methods for assessing risk of metastasis of a tumor in a mammal by determining the paxillin gene copy number per cell in the tumor or by detecting the presence of a paxillin mutation in the tumor. The presence of an increased paxillin gene copy number or a paxillin mutation is indicative of an increased risk of metastasis. Methods of staging tumors and methods of reducing invasiveness or metastasis of a cancer cell are also provided. Oligonucleotides comprising a paxillin mutation and antibodies capable of recognizing a paxillin mutant are disclosed.
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