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MAGNETIC-SENSITIVE MATERIAL, MAGNETIC-SENSITIVE MEDICINAL AGENT, AND THOSE PRODUCTION METHODS

机译:磁敏材料,磁敏药物和其他生产方法

摘要

Disclosed are: a magnetic-sensitive material in which a functional substance contained therein can be separated from a mixture readily by using a magnet; a magnetic-sensitive medicinal agent comprising a magnetic microparticle, an organic thin film covalently bound to the surface of the microparticle, and a medicinal agent bound and immobilized on the microparticle through the organic thin film, in which the pharmacokinetics of a medicinal agent contained therein can be controlled by using a magnet; and a process for producing each of the magnetic-sensitive material and the magnetic-sensitive medicinal agent. Specifically disclosed is a magnetic-sensitive material (10) which comprises: a magnetic microparticle (1); a thin film (4) formed by a film-like compound having a second functional group, which covers the magnetic microparticle (1); a cross-linking agent (5) having a first cross-linking group and a second cross-linking group, wherein the first cross-linking group can react with the second functional group to form a covalent bond, the second cross-linking group can react with a functional group in a functional substance (6) to form a bond, and the cross-linking agent (5) is bound to the surface of the thin film (4) via a covalent bond formed by the reaction between the second functional group and the first cross-linking group; and the functional substance (6) which is bound to the microparticle (1) via a bond formed by the reaction between the functional group in the functional substance (6) and the second cross-linking group.
机译:公开了一种磁敏材料,其中可以使用磁体容易地将其中包含的功能性物质与混合物分离。磁敏药物,其包含磁性微粒,与微粒表面共价结合的有机薄膜,以及通过有机薄膜结合并固定在微粒上的药物,其中所含药物的药代动力学可以用磁铁控制;以及制造磁敏材料和磁敏药物的方法。具体地公开了一种磁敏材料(10),其包括:磁性微粒(1);和磁性微粒(1)。由具有第二官能团的膜状化合物形成的薄膜(4),其覆盖磁性微粒(1);具有第一交联基团和第二交联基团的交联剂(5),其中第一交联基团可以与第二官能团反应形成共价键,第二交联基团可以与功能性物质(6)中的官能团反应形成键,并且交联剂(5)通过第二官能团之间的反应形成的共价键与薄膜(4)的表面结合组和第一个交联组;所述功能性物质(6)通过由功能性物质(6)中的官能团与第二交联基团之间的反应形成的键与微粒(1)结合。

著录项

  • 公开/公告号WO2008111538A1

    专利类型

  • 公开/公告日2008-09-18

    原文格式PDF

  • 申请/专利权人 OGAWA KAZUFUMI;WATANABE YOSHIAKI;

    申请/专利号WO2008JP54217

  • 发明设计人 OGAWA KAZUFUMI;WATANABE YOSHIAKI;

    申请日2008-03-07

  • 分类号A61K47/48;A61K9/14;A61K31/43;A61K47/02;

  • 国家 WO

  • 入库时间 2022-08-21 19:57:12

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