RESPIRATORY SYNCYTIAL VIRUS (RSV) CHIMERIC POLYPEPTIDE COMPRISING THE G PROTEIN CENTRAL REGION DOMAIN LOCATED IN BETWEEN THE F2 AND F1 FUSION PROTEIN DOMAINS

摘要

Chimeric respiratory syncytial virus (RSV) polypeptide antigens are provided. The disclosed polypeptides include in an N-terminal to C-terminal direction: a first F protein polypeptide domain; a G protein polyeptpide domain; and a second F protein polypeptide domain. The disclosure also provides nucleic acids that encode, and pharmaceutical compositions that contain, the chimeric RSV polypeptides, as well as methods for their production and use.