NOVEL GENE DELIVERY VECTORS FOR HUMAN MESENCHYMAL STEM CELLS

摘要

Novel gene delivery vector compositions that interact with human mesenchymal stem cells are provided, as well as methods of synthesizing and using such compositions. Such compositions may comprise a plurality of hyaluronic acid hexamers covalently attached to a branched polyethylenimine. Such methods of synthesis may comprise providing a plurality of hyaluronic acid hexamers and a branched polyethylenimine, andallowing a hexamer of hyaluronic acid to covalently attach to a branched polyethylenimine to form a conjugate. Such methods of use may comprise providing a conjugate comprising a plurality of hyaluronic acid hexamers covalently attached to a branched polyethylenimine, and administering the conjugate to a cell.