NUCLEIC ACID-BINDING CHIPS FOR DETECTING GLUCOSE DEFICIENCY CONDITIONS WITHIN THE SCOPE OF BIOPROCESS CONTROL

摘要

The invention relates to nucleic acid-binding chips for monitoring bioprocesses with special orientation toward the detection of glucose deficiency conditions. These chips support probes for at least six of the following 85 genes: yxe/, dppE, fruK, ybdN, yvdE, rbsK, hxIA, yvdH, ywfL, ispA, yvyD, licA, rocD, ycgO, yqiQ, sigX, iolC, licH, iolE, rsiX, mmgE, iolD, yvql, glpF, ysbA, yvqH, bpr, acdA, yvoA, aprE, yusK, acuA, acsA, acoR, ysiA, pgcM, mmgB, mmgD, tdh, mmgC, malP, mmgA, yusJ, malA, glpD, etfB, etfA, ywjF, yvdG, yusL, yvdl, acoC, acoL, ycgM, mmsA, ycgN, yoeB, kbl, yvdJ, yvdK, yfiA, malL, acoA, acoB or homologs to SEQ ID NO. 157, 39, 159, 103, 151, 125, 123, 63, 9, 49, 93, 35, 13, 105, 17, 15, 95, 99, 101, 107 or 11 with a maximum of 100 glucose metabolism-specific different probes. The invention also relates to the use of corresponding gene probes, particularly to chips of the aforementioned type, and to corresponding methods and possible uses.