RIBOSOMAL PROTEIN S3: A FUNCTIONAL COMPONENT OF NF-KAPPA B p65 BINDING COMPLEXES

摘要

The invention provides a method of inhibiting the expression of NF-kB target genes in a mammal comprising administering an effective amount of an inhibitor of ribosomal protein S3 (RPS3) to the mammal. The invention also provides a method of inhibiting the induction of immunoglobulin k light chain gene expression in B cells comprising administering an effective amount of an inhibitor of RPS3 to the B cells. The invention further provides a method of treating an inflammatory disease or disorder in a mammal comprising administering an effective amount of an inhibitor of RPS3 to the mammal.