首页> 外国专利> Melanin concentrating hormone receptor ligands : substituted 1-benzyl-4-aryl piperazine analogues.

Melanin concentrating hormone receptor ligands : substituted 1-benzyl-4-aryl piperazine analogues.

机译:黑色素浓缩激素受体配体:取代的1-苄基-4-芳基哌嗪类似物。

摘要

Melanin concentrating hormone receptor ligands (especially 1-benzyl-4-arylpiperazines, 1-benzyl-4-aryl-piperidines and related compounds), capable of modulating MCH receptor activity, are provided. Such ligands may be used to modulate MCH binding to MCH receptors in vivo or in vitro, and are particularly useful in the treatment of a variety of metabolic, feeding and sexual disorders in humans, domesticated companion animals and livestock animals. Pharmaceutical compositions and methods for treating such disorders are provided, as are methods for using such ligands for detecting MCH receptors (e.g., receptor localization studies).
机译:提供了能够调节MCH受体活性的黑色素浓缩激素受体配体(特别是1-苄基-4-芳基哌嗪,1-苄基-4-芳基哌啶和相关化合物)。这样的配体可用于体内或体外调节MCH与MCH受体的结合,并且特别用于治疗人,家养伴侣动物和家畜的各种代谢,喂养和性疾病。提供了用于治疗此类疾病的药物组合物和方法,以及使用此类配体检测MCH受体的方法(例如,受体定位研究)。

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