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A METHOD OF INTRAEPITHELIAL AND SYSTEMIC EXPOSURE OF THERAPEUTIC AGENTS FOLLOWING VAGINAL AND ORAL CAVITY ADMINISTRATION
A METHOD OF INTRAEPITHELIAL AND SYSTEMIC EXPOSURE OF THERAPEUTIC AGENTS FOLLOWING VAGINAL AND ORAL CAVITY ADMINISTRATION
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机译:阴道腔和口腔腔给药后治疗性上皮内和全身暴露的方法
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摘要
A vaginal or buccal delivery of therapeutic agents having a substrate affinity for metabolic cytochrome P-450 enzymes and membrane efflux transporter systems. A method for augmentation of systemic exposure to the therapeutic agents having a substrate affinity for cytochrome P-450 enzymes and membrane efflux transporter systems, by delivering said agents to the systemic circulation through vaginal or buccal mucosa.
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