METHOD FOR PRODUCING (R) - AND (S)-4-(1-AMMONIUMETHYL)BENZOIC ACID METHYLESTER-SULPHATE FROM RACEMIC 4-(1-AMINOETHYL)BENZOIC ACID METHYLESTER BY LIPASE CATALYSED ENANTOSELECTIVE ACYLATION AND SUBSEQUENT PRECIPITATION WITH SULPHURIC ACID

摘要

The invention relates to a method for producing optically active 4-(1-ammoniumethyl)-benzoic acid methylester-sulphate by reacting racemic 4-(1- aminoethyl)-benzoic acid methylester with an acylating agent in the presence of a lipase to form 4-(1-aminoethyl)benzoic acid methylester and subsequently, precipitation of 4-(1-ammoniumethyl)benzoic methylester-sulphate by adding sulphuric acid.