首页>
外国专利>
PHARMACEUTICAL COMPOSITIONS OF AN ORAL MEDICATION FOR IMPROVED DISSOLUTION RATE OF POORLY WATER SOLUBLE SIBUTRAMINE
PHARMACEUTICAL COMPOSITIONS OF AN ORAL MEDICATION FOR IMPROVED DISSOLUTION RATE OF POORLY WATER SOLUBLE SIBUTRAMINE
展开▼
机译:水溶性西布他明的溶出度提高的口服药物的药物成分
展开▼
页面导航
摘要
著录项
相似文献
摘要
Oral pharmaceutical compositions comprising sibutramine are provided to improve biocompatibility of sibutramine having no addition salts by improving solubility and dissolution rate of sibutramine having no addition salts which is poorly water-soluble and simply synthesized, so that they are useful for prevention and treatment obesity. An oral pharmaceutical composition for prevention and treatment obesity comprises 1 part by weight of sibutramine, 0.1-20 parts by weight of inorganic acid, 0.1-20 parts by weight of high molecular compound polymer of 1-40cp and 0.1-20 parts by weight of dispersing agent, wherein the inorganic acid is sulfuric acid, hydrochloric acid, nitric acid, phosphoric acid or carbonic acid; the high molecular compound polymer is saccharide, cellulose derivative, gum, protein, polyvinyl derivative, polymethacrylate copolymer or polyethylene derivative; and the dispersing agent is sodium starch glycolate, calcium carboxymethylcellulose, low substituted hydroxypropylcellulose, croscarmellose sodium, crospovidone, microcrystalline cellulose, hard anhydrous silicic acid, lactose or starch.
展开▼