NOVEL PHENYLPROPIONIC ACID DERIVATIVES AS PEROXISOME PROLIFERATOR-ACTIVATED ALPHA/GAMMA RECEPTOR AGONISTS, METHOD OF THE SAME, AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME

摘要

A phenylpropionic acid derivative is provided to lower the blood sugar and lipid in blood, and improve insulin resistance by simultaneously activating gamma and alpha peroxisome proliferator-activated receptors. A phenylpropionic acid derivative is represented by the formula(1) and is prepared by the method comprising the steps of: (a) reacting a compound represented by the formula(2), (3), or (4) with a compound represented by the formula(5); (b) reacting a cyanuric chloride represented by the formula(6); (c) reacting Y; (d) reacting Z; and (e) hydrolyzing. In the formulae, R is -OCH2CH3 or -CH2CH3; X is -NCH3, -NH, -O- or methylene; each Y and X is independently lower alkyl, lower alkoxy, lower cycloalkylamine, aniline, azetine, pyrrolidine, piperidine, piperazine, morpholine, thiomorpholine, phenyl, or phenoxy, provided that each defined substituent of the Y and Z may optionally have at least one substituent selected from the group consisting of C1-6 alkyl, C1-6 alkoxy, hydroxy, amino, nitro, trifluoromethyl, phenyl, benzyl, benzoyl, furan, thiophene, phenoxy, piperidine; n is an integer from 1 to 5; and W is methyl or ethyl. A therapeutic agent for diabetes or X-syndrome comprises the compound of the formula(1) or a pharmaceutically acceptable salt thereof as an effective ingredient.