METHODS FOR DIAGNOSING PREMATURE OVARIAN FAILURE USING POLYNUCLEOTIDES COMPRISING SINGLE NUCLEOTIDE POLYMORPHISM

摘要

Polynucleotides comprising single nucleotide polymorphism are provided to improve rapidness and accuracy of diagnosis of premature ovarian failure, especially of Korean female, so that the polynucleotides are useful as genetic markers for diagnosis of premature ovarian failure. A method for diagnosing the premature ovarian failure comprises the steps of: obtaining a nucleic acid sample from an isolated sample; and determining the nucleotide sequence of at least one single nucleotide polymorphism selected from polynucleotides of SEQ ID NO:1 to SEQ ID NO:10 by hybridizing the nucleic acid sample with a microarray containing one polynucleotide selected from (a) a polynucleotide comprising more than 10 consecutive DNA sequence containing a 201st base of SEQ ID NO:1, (b) a polynucleotide comprising more than 10 consecutive DNA sequence containing a 201st base of SEQ ID NO:2, (c) a polynucleotide comprising more than 10 consecutive DNA sequence containing a 131st base of SEQ ID NO:3, (d) a polynucleotide comprising more than 10 consecutive DNA sequence containing a 201st base of SEQ ID NO:4, (e) a polynucleotide comprising more than 10 consecutive DNA sequence containing a 201st base of SEQ ID NO:5, (f) a polynucleotide comprising more than 10 consecutive DNA sequence containing a 805th base of SEQ ID NO:6, (g) a polynucleotide comprising more than 10 consecutive DNA sequence containing a 201st base of SEQ ID NO:7, (h) a polynucleotide comprising more than 10 consecutive DNA sequence containing a 201st base of SEQ ID NO:8, (i) a polynucleotide comprising more than 10 consecutive DNA sequence containing a 201st base of SEQ ID NO:9 and (j) a polynucleotide comprising more than 10 consecutive DNA sequence containing a 501st base of SEQ ID NO:10.