THE THERAPEUTIC EFFECTS IN ACUTE LUNG INJURY

摘要

A therapeutic agent of acute lung injury is provided to inhibit vascular endothelial growth factor(VEGF) and reduce increased VEGF and vascular permeability, so that it is useful for treating increased inflammation response and induced airway hyperresponsiveness. A therapeutic agent of acute lung injury comprises N-acetyl-L-cysteine which inhibits VEGF in the lung tissue, and reduces exudation of blood plasma in the lung tissue and vascular permeability as an effective ingredient, and is formulated as ample or vial, powder, granule, tablet, injection or suspension. The acute lung injury is treated by orally administering 2-5 mmol/kg, preferably 3 mmol/kg of N-acetyl-L-cysteine to a patient in 3-5 times at an interval of 24 hours.