首页> 外国专利> METHOD OF DIAGNOSIS OF TOXICITY FOR POLYBROMINATED DIPHENYL ETHERS USING TARGET ORGAN-ARRAY AND PBDES-SPECIFIC PROTEINS

METHOD OF DIAGNOSIS OF TOXICITY FOR POLYBROMINATED DIPHENYL ETHERS USING TARGET ORGAN-ARRAY AND PBDES-SPECIFIC PROTEINS

机译:目标有机阵列和多溴二苯醚特异性蛋白诊断多溴二苯醚毒性的方法

摘要

A target-organ array set and a method for diagnosing exposure to a brominated compound and intoxication by the brominated compound are provided to identify the intoxication and contamination degree of the brominated compound easily by identifying a change of a protein which shows specific change in an organ sensitively influenced by the brominated compound. A target-organ array set for diagnosing exposure to a brominated compound and intoxication by the brominated compound comprises: a control sample adhesion portion where at least one selected from the group consisting of pituitary tissue, a thyroid tissue, a liver tissue and a prostatic tissue of a normal group is attached to the surface; and an adhesion portion to be measured where a sample to be measured regarding a control group is adhered. An antibody set for diagnosing exposure to the brominated compound and intoxication by the brominated compound comprises at least one antibody selected from the group consisting of an anti-pregnane X receptor antibody, anti-apolipoprotein A-1 antibody, anti Bcl-2 antibody, anti-cytochrome P4501A1 antibody, anti UDP-glucuronosyltransferase 1A antibody, and anti androgen receptor antibody.
机译:提供一种靶器官阵列组和诊断对溴化化合物的暴露和被溴化化合物中毒的方法,以通过鉴定显示器官中特定变化的蛋白质的变化来容易地鉴定溴化化合物的中毒和污染程度。受到溴化合物的敏感影响。一种用于诊断接触溴化化合物和溴化化合物中毒的靶器官阵列,其包括:对照样品粘附部分,其中至少一种选自垂体组织,甲状腺组织,肝组织和前列腺组织正常基团的一部分附着在表面上;待测物附着在与对照组有关的待测样品上。用于诊断暴露于溴化化合物和被溴化化合物中毒的抗体组包括至少一种选自抗孕烯X受体抗体,抗载脂蛋白A-1抗体,抗Bcl-2抗体,抗-细胞色素P4501A1抗体,抗UDP-葡萄糖醛酸转移酶1A抗体和抗雄激素受体抗体。

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