METHOD FOR MODIFYING SURFACE OF HYDROXYAPATITE NANO-CRYSTAL

摘要

A modification method of the surface of hydroxyapatite nano-crystal is provided to obtain hydroxyapatite nano-crystal having excellent dispersibility and improved mechanical property by grafting polymerization of biodegradable polymer on the nano-crystal through modulating the reactivity of the hydroxyl group on the surface of the hydroxyapatite nano-crystal. A modification method of the surface of hydroxyapatite nano-crystal comprises a step of introducing a primary alcohol group to the hydroxyl group on the surface of the hydroxyl group on the surface of the hydroxyapatite nano-crystal for the grafting polymerization of a biodegradable polymer. The hydroxyl group is the hydroxyl group introduced by ethylene glycol in a one-pot reaction of hexamethylenediisocyanate and ethylene glycol. The biodegradable polymer is selected from a group consisting of polylactide, polyglycolide, polycaprolactone, polytrimethylene carbonate, and combinations thereof. The amount of the biodegradable polymer is 20-30wt%. Further, a weight average molecular weight of the biodegradable polymer is 10000 to 100000 g/mol.