FUSION PROTEIN OF E. COLI HEAT-LABILE ENTEROTOXIN SUBUNIT B AND EPITOPE OF NEURAMINIDASE OF NEWCASTLE DISEASE VIRUS AND USE THEREOF

摘要

A fusion protein of Escherichia coli enterotoxin protein and a neuraminidase epitope of Newcastle disease virus is provided to increase immunity against Newcastle disease virus in poultry, so that the protein is useful for prevention of Newcastle disease virus. A fusion protein of E. coli heat-labile enterotoxin subunit B and a neuraminidase epitope of Newcastle disease virus has the amino acid sequence of SEQ ID NO:1. A polynucleotide encoding the fusion protein has the nucleotide sequence of SEQ ID NO:2. An expression vector pLD-CtV-HN contains the polynucleotide of SEQ ID NO:2. A vaccine composition for preventing Newcastle disease virus contains the fusion protein as an effective ingredient. The immunity against Newcastle disease virus in poultry is increased by administering the fusion protein or a transgenic plant containing the expression vector pLD-CtV-HN into poultry.