首页> 外国专利> METHOD FOR TREATING ALPHA-MELANOCYTE-STIMULATING HORMONE FOR PROTECTING ISLET CELLS FOR TRANSPLANTATION

METHOD FOR TREATING ALPHA-MELANOCYTE-STIMULATING HORMONE FOR PROTECTING ISLET CELLS FOR TRANSPLANTATION

机译:治疗用于移植的胰岛细胞的α-黑素细胞刺激激素的治疗​​方法

摘要

A method for protecting islet cells during transplantation is provided to increase the transplantation efficiency by efficiently preventing destruction of the islet cells or damage of insulin secretion capacity of the islet cells caused by the islet cell transplantation and improve the transplantation success rate by inducing the stability of the islet cells at an initial stage of the transplantation. A method for treating an alpha-melanocyte-stimulating hormone for protecting islet cells for transplantation is characterized in that the alpha-melanocyte-stimulating hormone is added to a predetermined step during a series of the islet cells transplantation which isolates the islet cells from an animal islet cell supplying source except human and transplants the islet cells into an animal except human, wherein the predetermined step is at least one selected from the group consisting of an islet cell isolation step from the islet cell supplying source, an islet cell culturing step, an in vitro operating step of the islet cell, an islet cell storing step, and an islet cell transplanting step into a donor of the cell and the alpha-melanocyte-stimulating hormone adding step consists of adding the alpha-melanocyte-stimulating hormone to blood monocytes and then adding the alpha-melanocyte-stimulating hormone mixed with the blood monocytes to the islet cells.
机译:本发明提供了一种在移植过程中保护胰岛细胞的方法,以通过有效地防止胰岛细胞移植引起的胰岛细胞的破坏或胰岛细胞胰岛素分泌能力的损害来提高移植效率,并通过诱导其稳定性来提高移植成功率。移植初期的胰岛细胞。一种用于保护胰岛细胞用于移植的刺激α-黑素细胞的激素的方法,其特征在于,在将胰岛细胞与动物分离的一系列胰岛细胞移植期间,将α-黑素细胞的激素添加至预定步骤。除了人以外的胰岛细胞供给源,将胰岛细胞移植到人以外的动物中,其中,预定步骤是选自从胰岛细胞供给源的胰岛细胞分离步骤,胰岛细胞培养步骤,胰岛细胞的体外操作步骤,胰岛细胞储存步骤和向细胞供体的胰岛细胞移植步骤以及添加α-黑素细胞的激素的添加步骤包括向血液单核细胞添加α-黑素细胞的激素然后将与血液单核细胞混合的α-黑素细胞刺激激素添加到胰岛细胞中。

著录项

  • 公开/公告号KR100819838B1

    专利类型

  • 公开/公告日2008-04-07

    原文格式PDF

  • 申请/专利权人 PWG GENETICS KOREA LTD.;

    申请/专利号KR20060105355

  • 发明设计人 KIM SONG CHEOL;RYOO THOMAS;

    申请日2006-10-27

  • 分类号C07K14/685;

  • 国家 KR

  • 入库时间 2022-08-21 19:52:15

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