DIAGNOSTIC BIOMARKER FOR LUNG ADENOCARCINOMA ISOLATED FROM SERUM GLYCOPROTEINS

摘要

A marker for diagnosing lung cancer is provided to be specifically over-expressed in serum of lung cancer patients, thereby being very useful for diagnosing the lung cancer and evaluation progress state of a disease and prognosis before and after treatment. A composition for diagnosing lung cancer comprises an antibody specifically coupled to a protein selected from the group consisting of complement component c8 beta chain precursor, protein s100-a9, C4b-binding protein alpha chain precursor, isoform 2 of apolipoprotein-l1 precursor, protein s100-a8, similar to cavia porcellus phosphatidic acid phosphatase 2A mRNA, complement component c9 precursor, inter-alpha-trypsin inhibitor heavy chain h3 precursor, Flj00385 protein(fragment), coagulation factor xii precursor, Ig alpha-2 chain c region, complement component c8 alpha chain precursor, corticosteroid-binding globulin precursor, clusterin precursor, gamma-g globin, serum amyloid p-component precursor, plasma kallikrein precursor, Igha1 protein, heparin cofactor 2 precursor, 16kDa protein, Ig kappa chain v-iii region gol, complement factor I precursor, hemoglobin subunit beta, similar to tripartite motif protein 49, isoform 1 of complement factor b precursor(fragment), alpha-1-antitrypsin precursor, carboxypeptidase n subunit 2 precursor, complement factor h-related protein 3 precursor, plasma protease c1 inhibitor precursor, Ig kappa chain c region, alpha 2 macroglobulin variant, dermcidin precursor, complement c5 precursor and pregnancy zone protein precursor. A kit for diagnosing lung cancer includes an antibody specific to an inter-alpha-trypsin inhibitor heavy chain h3 precursor(ITI-H3). A microarray for diagnosing the lung cancer is characterized in that the antibody specific to the ITI-H3 is attached thereto.