Bio-degradable nanoparticles of polyDL-lactide-co-glycolide encapsulating ciprofloxacin HCl having extended-release properties, and manufacturing method thereof

摘要

The present invention relates to a method and release biodegradable nanoparticles and a production stand of polylactide glycolide copolymers ciprofloxacin is supported. More specifically, the present invention is by the release and biodegradable porous nanoparticles, and the W / O / W emulsion solvent evaporation process has a particle size of 100-500nm standing of ciprofloxacin is supported on the inside polylactide glycolide copolymers dissolving at a concentration of a process for producing a particulate water-soluble drugs are supported: (1) 2-6% of polylactide glycolide in dichloromethane (w / v, g / ml); (2) dissolving in distilled water at a concentration of ciprofloxacin to 1-2% (w / v, g / ml); Of a mixture such that one next 30 to 40 watts (W) to the sonicator: the ratio by weight of ciprofloxacin 8-10: (3) said polylactide glycolide is dissolved in dichloromethane solution and the aqueous solution of ciprofloxacin polylactide glycolide treated for 1-3 minutes with 10ml per output stage to create a W / O emulsion; And (4) the W / O emulsion to again 1.0% (w / v) aqueous polyvinyl alcohol solution to put the high-pressure homogenizer (High-pressure homogenizer) to 600 ~ 800 bar in 100ml per minute every 5-7 cycles during treatment to have a particle size of 100-500nm comprising the step of making a W / O / W emulsion, provides a release method, and a biodegradable porous nanoparticles are supported on the inner stand of the ciprofloxacin polylactide glycolide copolymers. ; The supported nanoparticle manufactured according to the present invention is ciprofloxacin ; Since the manufacture of poly lactide, glycolide copolymers, as well as there are no side effects and immune rejection in humans, and especially advantageous for the administration of it can be adjusted to be a week or more drugs slowly released after administration require frequent administration of short serum half-life of the drug, after both the drug release is not required that the copolymer that functions as a carrier to remove the nanoparticles eliminating decomposes naturally in the human body separately. In addition, the present invention is a polylactide glycolide mixed solution was dissolved in distilled water and the ciprofloxacin is dissolved in dichloromethane, made a W / O emulsion as a sonicator, and then again polyvinyl alcohol put in a high pressure homogenizer (High-pressure homogenizer with an aqueous solution ) ciprofloxacin to easily provide a new method capable of producing nanoparticles is supported between 100-500nm using. ; Ciprofloxacin, polylactide glycolide copolymers, nanoparticles