PHYSIOLOGICALLY ACTIVE SUBSTANCE EEM-S ORIGINATING IN MUSHROOMS, PROCESS FOR PRODUCING THE SAME AND DRUGS

摘要

EEM-S having a molecular weight of 6000-60000 and obtained by: (i) extracting organisms such as Lentinus edodes, Flammulina velutipes, Hypsizigus marmoreus, Ganoderma lucidumand/or Phellinus yucatensiswith hot water or lower alcohol; and (ii) treating the extract with molecular sieves to remove the low molecular weight and high molecular weight fractions. EEM-S is claimed having a molecular weight of 6000-60000 and obtained by: (i) extracting Lentinus edodes, Flammulina velutipes, Hypsizigus marmoreus, Pleurotus ostreatus, Pholiota nameko, Grifola fondosa, Volvariella speciosa var.speciosa, Lyophyllum decastes, blanc du pays, Tricholoma matsutake, Ganoderma lucidumand/or Phellinus yucatensiswith hot water or lower alcohol; and (ii) treating the extract with molecular sieves to remove the low molecular weight and high molecular weight fractions. ACTIVITY : Cytostatic; immunostimulator; hypotensive; antidiabetic. EEM-SB administered to mice implanted with BDF 1cells at 500 mg/kg/day for 20 days increased survival time by 45.8%. MECHANISM OF ACTION : Antioxidant; hypoglycemic.