An apoptosis inhibiting agent is provided to prevent activation of the apoptosis by digesting a Cdc6 protein during the apoptosis process, thereby being usefully used to prevent or treat degenerative diseases induced by abnormal apoptosis such as Alzheimer's disease and Parkinson's disease. An apoptosis inducing agent comprising a p32-tCdc6 protein is provided to show strong apoptosis inducing effect, thereby being usefully used to prevent or treat various cancer diseases induced by abnormal proliferation. An apoptosis inhibiting protein includes 1-290 amino acid sequences of a Cdc6 protein described in SEQ ID : NO. 1 and is characterized in that it includes an amino acid sequence substituted by point mutation of a 290 amino acid and a 442 amino acid. An apoptosis inducing composition includes 1-290 amino acid sequences of a Cdc6 protein described in SEQ ID : NO. 3. An agent for inhibiting apoptosis or treating degenerative diseases comprises the apoptosis inhibiting protein, a gene encoding the protein, or an expression vector including the gene. An agent for inducing apoptosis or treating auto-immune diseases or cancer comprises the apoptosis inducing protein, a gene encoding the protein, or an expression vector including the gene.
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机译:提供了一种凋亡抑制剂,以通过在凋亡过程中消化Cdc6蛋白来防止凋亡的激活,从而可有效地用于预防或治疗由异常凋亡引起的变性疾病,例如阿尔茨海默氏病和帕金森氏病。提供包含p32-tCdc6蛋白的凋亡诱导剂以显示出强的凋亡诱导作用,从而可有效地用于预防或治疗由异常增殖诱导的各种癌症。凋亡抑制蛋白包括SEQ ID NO:1中描述的Cdc6蛋白的1-290个氨基酸序列。图1的特征在于其包含被290个氨基酸和442个氨基酸的点突变取代的氨基酸序列。凋亡诱导组合物包括SEQ ID NO:1中描述的Cdc6蛋白的1-290个氨基酸序列。 3.用于抑制细胞凋亡或治疗退行性疾病的试剂包括细胞凋亡抑制蛋白,编码该蛋白的基因或包括该基因的表达载体。用于诱导凋亡或治疗自身免疫疾病或癌症的试剂包括凋亡诱导蛋白,编码该蛋白的基因或包括该基因的表达载体。
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