AGENT 'ecdysterone-80', have heart, adaptogenic, anti-hypoxic, gastroprotective, TERMOPROTEKTORNOY, anabolic and act-protective activity and manufacturing processes

摘要

1. application of u0444u0438u0442u043eu044du043au0434u0438u0441u0442u0435u0440u043eu0438u0434u043eu0432 comprising not less than 80% 20 - u0433u0438u0434u0440u043eu043au0441u0438u044du043au0434u0438u0437u043eu043du0430, 8 - 11% 25S - u0438u043du043eu043au043eu0441u0442u0435u0440u043eu043du0430 and 5.9 - 9.8% u044du043au0434u0438u0437u043eu043du0430 received from the base of the u0440u0430u0441u0442u0435u043du0438u00a0 Serratula coro nata l.collected in the phase of growth or mass u0431u0443u0442u043eu043du0438u0437u0430u0446u0438u0438 before u0446u0432u0435u0442u0435u043du0438u00a0, as u043au0430u0440u0434u0438u043eu043fu0440u043eu0442u0435u043au0442u043eu0440u043du043eu0433u043e, u0430u0434u0430u043fu0442u043eu0433u0435u043du043du043eu0433u043e, u0430u043du0442u0438u0433u0438u043fu043eu043au0441u0438u0447u0435u0441u043au043eu0433u043e, u0433u0430u0441u0442u0440u043eu043fu0440u043eu0442u0435u043au0442u043eu0440u043du043eu0433u043e , u0442u0435u0440u043cu043eu043fu0440u043eu0442u0435u043au0442u043eu0440u043du043eu0433u043e, u0430u043du0430u0431u043eu043bu0438u0447u0435u0441u043au043eu0433u043e and u0430u043au0442u043eu043fu0440u043eu0442u0435u043au0442u043eu0440u043du043eu0433u043e means.;2. method of manufacturing resources, u043fu0440u0435u0434u0441u0442u0430u0432u043bu00a0u044eu0449u0435u0433u043e sum u0444u0438u0442u043eu044du043au0434u0438u0441u0442u0435u0440u043eu0438u0434u043eu0432 comprising grinding the base mass u0440u0430u0441u0442u0435u043du0438u00a0 Serratula coronata l.collected in the phase of mass u0431u0443u0442u043eu043du0438u0437u0430u0446u0438u0438 before u0446u0432u0435u0442u0435u043du0438u00a0, extractions with a mixture of water and ethanol, the extract, vacuum concentration, whitening u0444u0438u043bu044cu0442u0440u043eu0432u0430u043d u0438u0435u043c through u0441u043eu0440u0431u0435u043du0442, u044du043bu044eu0438u0440u043eu0432u0430u043du0438u0435 u0444u0438u0442u043eu044du043au0434u0438u0441u0442u0435u0440u043eu0438u0434u043eu0432 with sorbent, pooling of fractions, u043fu0435u0440u0435u043au0440u0438u0441u0442u0430u043bu043bu0438u0437u0430u0446u0438u044e u0444u0438u0442u043eu044du043au0434u0438u0441u0442u0435u0440u043eu0438u0434u043eu0432 and drying the product, u043eu0442u043bu0438u0447u0430u044eu0449u0438u0439u0441u00a0 however,what vegetable raw materials at least read several others u043du0430u0441u0442u0430u0438u0432u0430u043du0438u0435u043c pre process the u043au0438u043fu00a0u0449u0435u0439 water per unit consumption of 2.6 l / kg u0441u044bu0440u044cu00a0 within 20 min, and then s u0432u043eu0434u00a0u043du044bu043c steam temperature 100u0441 with stomatal consumption 0.03, 0.09 kg / kg for 1 - 3 minutes, or mix with water with a certain consumption 3.5 l / kg and're warming their microwave pe chi to 100u0441,slurry u044du043au0441u0442u0440u0430u0433u0435u043du0442 - raw materials processing the ultrasound with a specific capacity of 39 w / l for 5 min, consistent u0442u0440u0435u0445u043au0440u0430u0442u043du043e u044du043au0441u0442u0440u0430u0433u0438u0440u0443u044eu0442 u043du0430u0441u0442u0430u0438u0432u0430u043du0438u0435u043c 70 to 96% of th u0430u043du043eu043bu043eu043c in u0433u0438u0434u0440u043eu043cu043eu0434u0443u043bu0435 process 1: (9 to 15) for 4.5 to 36 h, u043eu0442u0434u0435u043bu00a0u044eu0442 u0444u0438u043bu044cu0442u0440u043eu0432u0430u043du0438u0435u043c extract and concentrate in a vacuum at a temperature of not more than between, then extract u043eu0441u0432u0435u0442u043b u00a0u044eu0442 u0444u0438u043bu044cu0442u0440u043eu0432u0430u043du0438u0435u043c through u0441u043eu0440u0431u0435u043du0442 u043cu0445u043eu0443 formula (where m = si or mg.or al, x = 1 or 2, i = 1 to 3) or a mixture of these questions, u043eu0441u0432u0435u0442u043bu0435u043du043du044bu0439 extract are u043fu0440u0435u0446u0438u043fu0438u0442u0430u0446u0438u0438 on oxide with an u0430u043bu044eu043cu0438u043du0438u00a0 dry the rest of the u0441u043eu0440u0431u0435u043du0442 1: 9 with the following next drying in a vacuum, the precipitation is in u0434u043bu00a0 column flash chromatography over oxide u0430u043bu044eu043cu0438u043du0438u00a0 u0434u0438u0441u043fu0435u0440u0441u043du043eu0441u0442u0438 40 to 80 microns and u044du043bu044eu0438u0440u0443u044eu0442 u0444u0438u0442u043eu044du043au0434u0438u0441u0442u0435u0440u043eu0438u0434u044b mixture yu ethyl acetate - ethanol with gradient ethanol concentration from 0% to 96%.u043fu0435u0440u0435u043au0440u0438u0441u0442u0430u043bu043bu0438u0437u0430u0446u0438u044e u0444u0438u0442u043eu044du043au0434u0438u0441u0442u0435u0440u043eu0438u0434u043eu0432 u043eu0441u0443u0449u0435u0441u0442u0432u043bu00a0u044eu0442 have a mixture of ethyl acetate and ethanol and once from anhydrous ethanol with cooling to - 72u0441 with intermediate u0444u0438u043bu044cu0442u0440u043eu0432u0430u043du0438u0435u043c.