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METHOD FOR INTRODUCING A PNK MOLECULE CONJUGATED WITH A POSITIVE CHARGED PEPTIDE INTO CYTOSOL AND / OR PHOTOCHEMICAL INTERNALIZATION (PCI)
METHOD FOR INTRODUCING A PNK MOLECULE CONJUGATED WITH A POSITIVE CHARGED PEPTIDE INTO CYTOSOL AND / OR PHOTOCHEMICAL INTERNALIZATION (PCI)
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机译:将与正电荷肽结合的PNK分子引入细胞溶胶和/或光化学内部化(PCI)的方法
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摘要
The present application relates to a method for introducing a PNA molecule into the cytosol, preferably the nucleus of a cell, comprising contacting said cell with a PNA molecule and a photosensitising agent, and irradiating the cell with light of a wavelength effective to activate the photosensitising agent, wherein said PNA molecule is conjugated to a positively charged peptide. Compositions comprising such conjugated PNA molecules, cells made using the method and uses of the method are also described.
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