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METHOD FOR TREATING PATIENTS WITH GLIAL CEREBRAL TUMORS

机译:治疗脑胶质瘤患者的方法

摘要

FIELD: medicine, neurooncology.;SUBSTANCE: the present innovation deals with treating patients at low-differentiated cerebral gliomas. The method deals with introduction of anti-tumor chemopreparations. So, at first, one should catheterize common carotid artery (CCA) through a surface temporal artery at the side of the tumor, moreover, the catheter should be guided 1 cm below CCA bifurcation. Out of catheterized CCA one should sample 30 ml arterial autoblood into a syringe that contains 1 ml citrate conservant; then it should be supplemented with anti-tumor chemopreparations in therapeutic dosages. The mixture obtained should be incubated in a thermostat at 37°C for 1 h and introduce under the pressure and through the catheter into a patient's CCA once for 2 h. If necessary, this procedure should be repeated in 2 mo. The innovation provides decreased sizes or the absence of further tumor growth due to creating high concentration of chemopreparations directly in the tumor while they pass hematoencephalic barrier at their introduction upon autoblood and it considerably prolongs life duration in such patients.;EFFECT: higher efficiency of therapy.;1 ex
机译:领域:医学,神经肿瘤学;实体:本发明涉及低分化脑神经胶质瘤患者的治疗。该方法涉及抗肿瘤化学制剂的引入。因此,首先,应该通过肿瘤侧面的颞颞动脉对颈总动脉(CCA)进行导管插入,此外,导管应在CCA分叉下方1 cm处引导。从导管插入的CCA中,应将30 ml的动脉自血样品取样到装有1 ml柠檬酸盐防腐剂的注射器中。然后应以治疗剂量补充抗肿瘤化学制剂。所获得的混合物应该在37℃的恒温器中温育1小时,并在压力下并通过导管引入患者的CCA一次,持续2小时。如有必要,应在2个月内重复此过程。由于在血液中引入化学制剂时会直接通过血脑屏障,而在血液中经过血脑屏障时直接在肿瘤中产生高浓度的化学制剂,因此该创新技术可减小肿瘤的大小或不进一步肿瘤生长;效果:提高治疗效率。; 1前

著录项

  • 公开/公告号RU2310479C1

    专利类型

  • 公开/公告日2007-11-20

    原文格式PDF

  • 申请/专利权人 BALJAZIN IGOR VIKTOROVICH;

    申请/专利号RU20060128320

  • 发明设计人 BALJAZIN IGOR VIKTOROVICH;

    申请日2006-08-03

  • 分类号A61M1/36;

  • 国家 RU

  • 入库时间 2022-08-21 19:50:57

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