YEAST STRAIN Pichia pastoris PS106(pHIG) AS PRODUCER OF HUMAN IMMUNE INTERFERON, RECOMBINANT PLASMID pHIG AND METHOD FOR ITS DESIGN

摘要

FIELD: biotechnology, microbiology.;SUBSTANCE: invention relates to yeast strain Pichia pastoris PS106(pHIG) that represents a producer of human immune interferon, to recombinant plasmid used for transformation of this strain, and to a method for design of such plasmid. Invention provides preparing a recombinant gamma-interferon that can be secreted into cultural fluid in industrial scales. Advantage of invention involves the development of plasmid able to produce recombinant gamma-interferon for large-scale production.;EFFECT: valuable properties of yeast strain.;3 cl, 2 dwg, 3 ex