where R=-NHCH2C6H5 (I); -N(CH3)2 (II), as antiphlogistic medicines. The compound (I) is produced by 2-furyl-6-iodo-3,1-benzoxazine-4(3H)-one and benzylamide interreaction. The compound (II) is produced by 2-furyl-6-iodo-3,1-benzoxazine-4(3H)-one and dimethylamide interreaction. These substances represent white crystalline matters, insoluble in water, and soluble in ethanol, DMSO, DMFA. The retardation of edema development for compound (I) rates to 78.1% during the first hour, and 69.2%, 50.9% after 3 and 5 hours respectively. The acute toxicity (LD50) of substances presented amounts to 2240 (1900÷2500) mg/kg for I, and 7080 (6200÷8000) mg/kg for II.;EFFECT: substances have anti-inflammatory activity.;1 cl, 1 tbl"/>
N-(2-FURANOYL)-5-IODOANTHRANYLIC ACID BENZYLAMIDE AND N-(2-FURANOYL)-5-IODOANTHRANYLIC ACID DIMETHYLAMIDE APPLICATION AS ANTIPHLOGISTIC MEDICINES
FIELD: chemistry, pharmacology.;SUBSTANCE: invention relates to N-(2-furanoyl)-5-iodoanthranylic acid amides class, particularly to application of N-(2-furanoyl)-5-iodoanthranylic acid benzylamide (I) and N-(2-furanoyl)-5-iodoanthranylic acid dimethylamide (II), with formula where R=-NHCH2C6H5 (I); -N(CH3)2 (II), as antiphlogistic medicines. The compound (I) is produced by 2-furyl-6-iodo-3,1-benzoxazine-4(3H)-one and benzylamide interreaction. The compound (II) is produced by 2-furyl-6-iodo-3,1-benzoxazine-4(3H)-one and dimethylamide interreaction. These substances represent white crystalline matters, insoluble in water, and soluble in ethanol, DMSO, DMFA. The retardation of edema development for compound (I) rates to 78.1% during the first hour, and 69.2%, 50.9% after 3 and 5 hours respectively. The acute toxicity (LD50) of substances presented amounts to 2240 (1900÷2500) mg/kg for I, and 7080 (6200÷8000) mg/kg for II.;EFFECT: substances have anti-inflammatory activity.;1 cl, 1 tbl
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机译：技术领域：本发明涉及N-（2-呋喃酰基）-5-碘邻氨基苯甲酸酰胺类，尤其涉及N-（2-呋喃酰基）-5-碘邻氨基苯甲酸苄基酰胺（I）和N-的应用（2-呋喃酰基）-5-碘基邻苯二甲酸二甲酰胺（II），其化学式为<图像文件=“ 00000002.GIF” he =“ 23” id =“ imag00000002” imgContent =“ undefined” imgFormat =“ GIF” wi =“ 52 “ />其中R = -NHCH 2 C 6 H 5 （I）; -N（CH 3 ） 2 （II），作为消炎药。化合物（I）是通过2-呋喃基-6-碘-3，1-苯并恶嗪-4（3H）-与苄酰胺相互作用而制得的。化合物（II）是通过2-呋喃基-6-碘-3，1-苯并恶嗪-4（3H）-与二甲酰胺相互作用而制得的。这些物质代表白色晶体，不溶于水，可溶于乙醇，DMSO，DMFA。化合物（I）在第一小时的浮肿形成延迟率分别为78.1％，3和5小时后分别为69.2％，50.9％。所呈示物质的急性毒性（LD 50 ）对I而言为2240（1900＆divide; 2500）mg / kg，对II而言为7080（6200divide; 8000）mg / kg。 -炎症活性。; 1 cl，1 tbl
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