Gene Therapy of Solid Tumors by Retroviral Arenavirus Glycoprotein-Pseudotyped Vectors

摘要

The present invention concerns the use of packaging cells which produce retroviral virions pseudotyped with arenavirus glycoprotein, for the manufacture of a pharmaceutical composition for the gene therapy of solid tumors. The invention further concerns the use of the virions which are produced by these packaging cells, for the manufacture of a pharmaceutical composition for the gene therapy of solid tumors. Furthermore, packaging cells which are suitable for this application and pharmaceutical compositions containing these cells are subject matter of the invention.