Use of diphenylmethylpiperazine derivatives for the manufacture of a medicament for suppressing the proliferation of fibroblasts

摘要

Diphenylmethylpiperazine derivatices which are anticancer agents characterized by being compounds represented by general formula Ä1Ü, salts thereof, derivatives thereof or prodrugs thereof: Ä1Ü wherein R represents ( alpha ) or ( beta ). Compared with the conventional anticancer agents, these anticancer agents are less toxic and exert an excellent carcinostatic effect on various solid cancers. Moreover, these anticancer agents inhibit the proliferation of fibroblasts, which makes them efficacious against pulmonary fibrosis and proliferative keloid lesion.