Use of CD34 or a derived polypeptide as a surface marker for gene transfer

摘要

The present invention concerns the use of CD34 or a polypeptide derived therefrom as cell-surface/gene transfer marker. In particular the object of the invention is a gene transfer vector and host cells transduced by the vector, the vector containing a transgene and a nucleic acid sequence coding for CD34, a fragment of the same, or a variant of the same. The vector is particularly suitable for use in procedures for identification and/or selection of genetically modified cells and in gene therapy. The invention thus further concerns kits for carrying out these procedures and the use of the vector in vitro and in vivo. IMAGE